Leading the Way in Discovery of Ecologically-Advanced Microbiome Ingredients

Why Ecology Matters

When probiotics are consumed and reach the gut, they are outnumbered by a million-to-one by the resident members of the gut microbiota. Therefore, to be successful as a probiotic and produce health benefits, strains must be able to grow in the gut, compete for resources, and produce beneficial end-products.

At Synbiotic Health, we have developed novel strain discovery platforms that rely on ecological principles. Based on these approaches, we have developed a portfolio of strains that are well adapted to the gut ecosystem of interest.

iVS-1, the Missing Microbe for Health & Longevity

B. adolescentis iVS-1® is the only clinically documented and commercially viable strain of B. adolescentis in the market. The strain has over a decade of research with two completed clinical trials, one additional clinical trial planned in 2024, and one patent granted & three patents pending.

Clinically Demonstrated Health Benefits:

Gut barrier integrity for immune health
GABA for sleep and stress reduction
Folate for memory, mood, and cognition
Lactose digestion
Gastrointestinal wellbeing

Our guidelines in our research approach:

1. To deliver optimum performance, strains must be common in the human gut microbiome.

Synbiotic Health uses proprietary in-vivo selection or in-vitro enrichment platforms to identify and characterize ecologically-fit and host-adapted strains.

2. Probiotic strains or synbiotics must be competitively superior.

Synbiotic Health’s research yields probiotic strains that, alone or combined with specific partner prebiotics, are able to out-compete other strains in the gut environment.

3. Synbiotic Health offerings must show a positive health outcome in a well-designed clinical trial.

Synbiotic Health’s ingredients are supported by randomized, controlled clinical studies confirming health benefits. Supporting data may also show that the ingredients achieve health benefits by positively modulating the gut microbiome.

4. Synbiotic Health products must be safe, regulatory compliant, and suitable for formulation into commercial products.

Synbiotic Health’s ingredients are supported by robust safety data, comply with relevant government regulations, and are backed by stability data to support use in appropriate product formats.