The discovery of iVS-1® began in 2010 at the University of Nebraska-Lincoln, where researchers developed a next-generation screening platform, the IVS Platform™, to study the behavior of probiotics within the microbiota utilizing selected prebiotic fibers.² ³ By feeding subjects the prebiotic GOS, Bifidobacteria levels markedly increased, particularly in one elite athlete who showed a significant response.⁴ 

From this specific microbiome, researchers isolated the most abundant strain and named it B. adolescentis iVS-1. Further studies confirmed its stability, safety and efficacy, including a clinical trial showing iVS-1 improved gut barrier function.⁵ Additional clinical trials are underway with expected completion by the end of 2025.

Pre-clinical Science of B. adolescentis iVS-1

GABA Production
Folate Production
Lactase Genes

iVS-1 excels in GABA production, which can provide a range of health benefits related to cognitive function, pain management, sleep quality and gut health. These benefits arise from GABA’s role as a key neurotransmitter in both the central nervous system and the gut, underscoring the importance of this compound in overall human health.

iVS-1 is a robust producer of folate, which can help improve DNA synthesis, red blood cell formation, cardiovascular health, cognitive function and immune support, amongst other benefits offered by this crucial nutrient.

As a formidable digester
of lactose due to the high number of lactase genes present in its genome, iVS-1 can enhance overall digestive comfort and nutritional status for those who struggle with lactose intolerance.

Pre-clinical Science of B. adolescentis iVS-1

GABA Production

iVS-1 excels in GABA production, which can provide a range of health benefits related to cognitive function, pain management, sleep quality and gut health. These benefits arise from GABA’s role as a key neurotransmitter in both the central nervous system and the gut, underscoring the importance of this compound in overall human health.

Folate Production

iVS-1 is a robust producer of folate, which can help improve DNA synthesis, red blood cell formation, cardiovascular health, cognitive function and immune support, amongst other benefits offered by this crucial nutrient.

Lactase Genes

As a formidable digester
of lactose due to the high number of lactase genes present in its genome, iVS-1 can enhance overall digestive comfort and nutritional status for those who struggle with lactose intolerance.

Clinical Science of B. adolescentis iVS-1

Gut Barrier
Symptom Score

In a human trial, iVS-1 reduced intestinal permeability after three weeks of daily supplementation. The probiotic strengthens gut barrier integrity by upregulating tight junction proteins, reducing gut inflammation, promoting a healthy gut microbiota balance, and stimulating mucin production to protect the gut lining.

A probiotic strain that efficiently digests lactose can alleviate lactose intolerance symptoms, improve calcium absorption, maintain gut bacteria balance, enhance gut health, and support long-term lactose digestion for a varied diet.

iVS-1 supplementation reduces lactose mal-digestion symptoms from dairy sources through direct lactase production, enhancing gut enzymatic activity, and supporting the gut barrier by reducing inflammation and harmful substance translocation.

Clinical Science of B. adolescentis iVS-1

Gut Barrier

In a human trial, iVS-1 reduced intestinal permeability after three weeks of daily supplementation. The probiotic strengthens gut barrier integrity by upregulating tight junction proteins, reducing gut inflammation, promoting a healthy gut microbiota balance, and stimulating mucin production to protect the gut lining.

Symptom Score

A probiotic strain that efficiently digests lactose can alleviate lactose intolerance symptoms, improve calcium absorption, maintain gut bacteria balance, enhance gut health, and support long-term lactose digestion for a varied diet.

iVS-1 supplementation reduces lactose mal-digestion symptoms from dairy sources through direct lactase production, enhancing gut enzymatic activity, and supporting the gut barrier by reducing inflammation and harmful substance translocation.

Clinical Science of B. adolescentis iVS-1

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